The works are expected to be completed at end-October, the operator said in a press release.
During the planned outage, the reactor will be reloaded with fresh nuclear fuel.
The planned works are part of a project for extending the operating lifespan of Unit 6.
Kozloduy's other 1,000 MW unit, Unit 5, is currently operating at full capacity, the plant operator said.
Kozloduy NPP remained with two operational units - Units 5 and 6 - after the country closed down four units of 440 MW each to address nuclear safety concerns of the European Union prior to its accession to the bloc. Bulgaria joined the EU in 2007.