All infected and contact birds will be culled on the farm where around 395,000 hens are reared, the agency said in a statement on Tuesday.
The Food Safety Agency has set up a three-kilometre prevention zone and a ten-kilometre surveillance zone around the farm, it added.
Over the past three weeks, the farm has produced over 8 million eggs, all of which were shipped abroad, Bulgaria's national radio broadcaster BNR said citing the owner of the poultry farm, Kalina Shirokova.